SAFE

Grape Seed Proanthocyanidins

Vitis vinifera seed OPC extract
Likely Safe V1 Verified Cardiovascular Herbs
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PubMed Studies
2,800
About

Grape seed OPCs for vascular integrity, antioxidant protection, and capillary strengthening. High ORAC and clinical evidence.

How it works (mechanism of action)

Modulates cardiovascular function via eNOS activation for vasodilation, inhibition of platelet aggregation, and venotonic effects strengthening venous wall integrity. Antioxidant effects protect LDL from oxidative modification reducing atherosclerosis progression.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralLikely safeNot established
PregnancyLikely safeNot established
ElderlyLikely safeNot established
🚫 Contraindications & Warnings

Very safe. Anticoagulant interaction. Allergy to grape products: caution.

🏷️ Other Names
Vitis vinifera seed OPC extract
Updated: 2026-04-02
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