SAFE

Fructose

D-Fructose (fruit sugar)
Possibly Safe V2 Verified Excipients & Additives
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PubMed Studies
735
PubChem CID
About

Simple monosaccharide found naturally in fruits and honey. Used as sweetener and tablet excipient. Metabolised primarily in liver via fructokinase. High-dose fructose associated with metabolic syndrome.

How it works (mechanism of action)

Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralPossibly safeNot established
PregnancyPossibly safeNot established
ElderlyPossibly safeNot established
🚫 Contraindications & Warnings

Hereditary fructose intolerance (HFI): ABSOLUTELY CONTRAINDICATED — life-threatening fructose metabolism disorder. GOUT: Fructose increases uric acid synthesis. Metabolic syndrome: very high fructose intake associated with non-alcoholic fatty liver disease (NAFLD), dyslipidaemia, insulin resistance. IBS/FODMAP: fructose malabsorption triggers GI symptoms in sensitive individuals.

🇪🇺 EU Health Claims Status
Art.13(1)
✓ Authorised
In order to bear the claim, glucose and/or sucrose should be replaced by fructose in sugar-sweetened foods or drinks so that the reduction in content of glucose and/or sucrose, in these foods or drinks, is at least 30%.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ Authorised
Non-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food is not sufficiently defined to be able to be assessed and the claim could not therefore be substantiated.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ Authorised
Non-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ Authorised
Non-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
🏷️ Other Names
D-Fructose (fruit sugar)
Updated: 2026-04-11
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