SAFE
Endocannabinoid-related compounds
2-AG, AEA, PEA, OEA precursors and analogues
Possibly Safe
V2 Verified
Specialty Bioactives
PubMed Studies
1
About
Compounds affecting the endocannabinoid system including palmitoylethanolamide (PEA), oleoylethanolamide (OEA), and 2-arachidonoylglycerol (2-AG). PEA (Normast) is a registered pharmaceutical in Italy.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
👥 Safety by Population
🚫 Contraindications & Warnings
PEA: generally very safe with extensive clinical data. Not a CB1/CB2 agonist — different from cannabis-derived compounds. Drug interactions with NSAIDs (additive anti-inflammatory). Pregnancy: limited data for concentrated supplements. Legal status varies by jurisdiction for some compounds.
🏷️ Other Names
2-AG, AEA, PEA, OEA precursors and analogues