Dehydroepiandrosterone (DHEA)
DHEA is the most abundant adrenal steroid hormone, converted peripherally to both testosterone and oestrogen. Declines 80% from peak by age 75. Studied for adrenal insufficiency, menopausal symptoms, sexual function, bone density, and mood. BANNED as dietary supplement in Canada, UK, and many countries. Prescription-only in Germany.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
BANNED in Canada (Schedule IV controlled anabolic steroid), UK (prescription-only medicine), Australia (Schedule 4), Germany, France, Netherlands (prescription). Legal as supplement only in USA (DSHEA). Converts to testosterone and oestrogens — contraindicated in hormone-sensitive cancers (breast, ovarian, prostate, endometrial), pregnancy, lactation. Drug interactions: insulin, anticoagulants, antidepressants. Androgenic side effects: acne, hair loss, hirsutism in women. Sports: WADA banned substance.