SAFE

Codonopsis

Codonopsis pilosula (Dang Shen)
Likely Safe V1 Verified Adaptogens
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PubMed Studies
16
About

Milder, affordable alternative to Panax ginseng. Used in TCM for energy, immune function, and GI health.

How it works (mechanism of action)

Modulates hypothalamic-pituitary-adrenal (HPA) axis and sympathoadrenal system to normalise physiological responses to stress. Activates heat shock proteins and stress-response pathways providing non-specific resistance to physical, chemical, and biological stressors.

📊 Effectiveness
Energy and immune support
Evidence Grade C · 8 studies · n=620
Possibly Effective

Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralLikely safeNo established UL
🚫 Contraindications & Warnings

May lower blood sugar; monitor with antidiabetics.

🏷️ Other Names
Codonopsis pilosula (Dang Shen)
Updated: 2026-04-02
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