SAFE
Citrulline Malate 2-1
Citrulline malate 2:1 ratio
Likely Safe
V1 Verified
Sports Nutrition
PubMed Studies
2,200
PubChem CID
About
Most studied sports form: 2 citrulline to 1 malate. For muscular endurance, blood flow, and delayed fatigue.
How it works (mechanism of action)
Enhances exercise performance via substrate provision, haemodynamic effects (vasodilation via nitric oxide), or anabolic/anti-catabolic signalling (mTOR activation). Reduces exercise-induced oxidative stress and inflammatory cytokine production.
📊 Effectiveness
Exercise endurance
Evidence Grade A · 22 studies · n=3,200 · Meta-analysis available
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
Very safe. Mild GI effects at above 10g. Very popular in pre-workout formulas.
🏷️ Other Names
Citrulline malate 2:1 ratio