SAFE
Chamomile Apigenin
Matricaria chamomilla apigenin extract
Likely Safe
V1 Verified
Sleep Support
PubMed Studies
2,200
About
High-apigenin chamomile extract for GABA-A receptor binding, anxiety reduction, and sleep improvement.
How it works (mechanism of action)
Modulates GABAergic neurotransmission via GABA-A receptor allosteric modulation or GABA transaminase inhibition increasing inhibitory CNS tone. Activates melatonin synthesis or MT1/MT2 receptor pathways, or reduces cortisol secretion by modulating HPA axis activation.
📊 Effectiveness
Sleep and anxiety
Evidence Grade B · 12 studies · n=1,600
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
Allergy to Asteraceae. Pregnancy: avoid high doses. Anticoagulant: case reports with warfarin.
🏷️ Other Names
Matricaria chamomilla apigenin extract