SAFE

Celery Seed Extract

Apium graveolens standardised
Possibly Safe V1 Verified Liver Herbs
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PubMed Studies
3
About

Celery seed contains phthalides and apigenin with diuretic, anti-inflammatory, uricosuric (uric acid-lowering), and liver-supporting effects.

How it works (mechanism of action)

Provides hepatoprotective effects via antioxidant enzyme induction (GPx, SOD), NF-kB suppression reducing hepatocyte apoptosis, and cytochrome P450 modulation. Choleretic action stimulates bile flow and composition benefiting lipid digestion and hepatic detoxification.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralPossibly safeNot established
PregnancyPossibly safeNot established
ElderlyPossibly safeNot established
🚫 Contraindications & Warnings

Pregnancy: avoid medicinal doses. Allergy to Apiaceae. Photosensitivity. Thyroid medication interaction.

🏷️ Other Names
Apium graveolens standardised
References (1)
  1. European Commission. Regulation (EU) No 432/2012. Off J Eur Union. 2012;L 136:1-40.   Regulatory document   Source ↗

Evidence grades: SR = Systematic review / meta-analysis (highest) · RCT = Randomized controlled trial · Reg = Regulatory/official guidance

Updated: 2026-04-11
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