SAFE

Calcium sulfate

Calcium sulfate (gypsum, E516)
Possibly Safe V2 Verified Excipients & Additives
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PubMed Studies
66
PubChem CID
About

Inorganic calcium salt used as tablet filler, desiccant, and food additive. E516. Poorly soluble. Provides calcium at low bioavailability. Very inert excipient.

How it works (mechanism of action)

Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralPossibly safeNot established
PregnancyPossibly safeNot established
ElderlyPossibly safeNot established
🚫 Contraindications & Warnings

Very safe. Low calcium bioavailability from this form. Kidney stones: insoluble calcium salts theoretically relevant in very high calcium intake. Very safe at excipient quantities.

🏷️ Other Names
Calcium sulfate (gypsum, E516)
Updated: 2026-04-11
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