PubMed Studies
113
About
Spore-forming probiotic for gut health, immune support, and digestive regularity. No refrigeration needed.
How it works (mechanism of action)
Provides substrate for beneficial gut bacteria fermentation or directly modulates intestinal epithelial cell function. Produces or stimulates short-chain fatty acids (propionate, butyrate, acetate) providing colonocyte energy and modulating immune tolerance via GPR41/43 activation.
📊 Effectiveness
Digestive health
Evidence Grade B · 8 studies · n=640
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
Very safe. GRAS. Heat-resistant spore form highly stable.
🏷️ Other Names
Bacillus subtilis DE111