SAFE
Annatto extract (bixin, norbixin)
Bixa orellana seed extract (E160b)
Possibly Safe
V2 Verified
Excipients & Additives
PubMed Studies
480
About
Natural orange-yellow carotenoid pigment from Bixa orellana seeds. Contains bixin (fat-soluble) and norbixin (water-soluble). EFSA has reviewed safety — ADI set. Allergic reactions documented despite being a natural colour.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
👥 Safety by Population
🚫 Contraindications & Warnings
Allergic reactions: documented urticaria, angioedema, anaphylaxis — not rare. IgE-mediated allergy in atopic individuals. Must be declared on EU labels. Some sources of IgE reactivity independent of main food allergens. EFSA: acceptable daily intake established.
🏷️ Other Names
Bixa orellana seed extract (E160b)