Alpha-lipoic acid
Dithiolane antioxidant acting as enzyme cofactor and free radical scavenger in both aqueous and lipid compartments. Reduces endogenous lipoate, regenerates Vitamin C and E. Studied for diabetic neuropathy and metabolic syndrome.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
HYPOGLYCAEMIA: significant blood glucose lowering — additive with insulin and oral hypoglycaemics. Monitor blood glucose carefully in diabetes. Thiamine deficiency: depletes thiamine — contraindicated in thiamine deficiency. Drug interactions: chemotherapy (reduces efficacy by antioxidant mechanism — consult oncologist). Thyroid: may affect thyroid medication requirements. Pregnancy: insufficient data.