⚠️
Major drug interaction. This ingredient has clinically significant drug interactions. See Drug Interactions below before use.
SAFE

7-Keto DHEA

7-oxo-DHEA
Possibly Safe V1 Verified Specialty Nutrients
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PubMed Studies
680
PubChem CID
About

7-Keto DHEA is a non-hormonal DHEA metabolite that does not convert to sex hormones. Used for weight management, immune function, and anti-ageing.

How it works (mechanism of action)

Provides targeted nutritional substrate or pharmacological activity for specific biochemical pathways not adequately supported by standard dietary intake. Mechanism involves enzyme cofactor provision, receptor modulation, or membrane structural modification.

⚖️ Regulatory Status
💊
AU — Prescription only
DHEA is scheduled as a prescription-only medicine in Australia (Schedule 4). [source ↗]
💊
CA — Prescription only
DHEA is a controlled substance in Canada, available by prescription only. [source ↗]
👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralPossibly safeNot established
PregnancyPossibly safeNot established
ElderlyPossibly safeNot established
🚫 Contraindications & Warnings

Banned by some sports organisations. Drug interactions with immunosuppressants. Limited long-term data.

💊 Drug Interactions (6)
🔴 Tamoxifen
Major
Hormone antagonists
Management: CONTRAINDICATED in oestrogen receptor positive breast cancer patients on tamoxifen.
🔴 Tamoxifen / Anastrozole
Major
Chemotherapy
Management: Contraindicated with hormone-sensitive cancer treatments.
🟡 Insulin
Moderate
Antidiabetics
Management: Monitor blood glucose in diabetics taking DHEA.
🟡 Corticosteroids
Moderate
Immunosuppressants
Management: Monitor when combining. May reduce corticosteroid efficacy.
🟡 Warfarin
Moderate
Anticoagulants
Management: Monitor INR with DHEA supplementation.
⚪ SSRIs
Minor
Antidepressants
Management: Discuss with prescriber. Monitor for mood and side effects.
Updated: 2026-04-11
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