1 Product identity

Ingredient risk

Contains a high-risk ingredient

PLUS

Name: PLUS
Brand: Mannatech

BrandMannatech→Other Combinations Other (e.g. tea bag) 24 ingredients 1 high-risk 1 caution DSLD #34898

Net contents: 90 Caplet(s)

Target: Adults and Children 4 years and above

DSLD entry: 2014-07-25

2 Ingredients (24)

IngredientGroupSafety

CaloriesCalories—

ProteinProtein (unspecified)—

Wild Yam extractWild YamConditionally Safe

standardized to 12.5% DiosgeninDiosgenin—

L-Glutamic AcidGlutamic Acid—

GlycineGlycineGenerally Safe

L-LysineLysine—

L-ArginineArginine—

Beta-SitosterolBeta Sitosterol—

Ambrotose ComplexTBD—

ArabinogalactanArabinogalactan—

Aloe veraAloe—

Ghatti GumGhatti—

Gum TragacanthTragacanth—

BoronBoronConditionally Safe

Microcrystalline CelluloseCellulose—

Stearic AcidStearic Acid—

Croscarmellose SodiumCroscarmellose Sodium—

Silicon DioxideSiliconGenerally Safe

HypromelloseHypromellose—

Calcium CarbonateCalciumConditionally Safe

Medium Chain TriglyceridesMedium chain triglycerides (MCT)—

Magnesium StearateMagnesium stearateUse with Caution

XylitolXylitolHigh risk

Ingredient amounts require the full DSLD label. View full label at NIH DSLD →

⛔ High-risk ingredient — documented serious harm

Xylitol — Dog owner not warned about xylitol toxicity — potentially fatal to dogs [1]

⚠️ Use with caution — restricted in some markets

Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].

3 Safety cross-reference

Wild Yam — Conditionally Safe

⚠ Does NOT convert to progesterone in body despite marketing claims

⚠ Estrogenic effects

Glycine — Generally Safe

⚠ Well tolerated

L-Lysine — Limited Evidence

⚠ GI discomfort at high doses

⚠ May increase calcium absorption

L-Arginine — Limited Evidence

⚠ Hypotension

⚠ May worsen herpes outbreaks

Boron — Conditionally Safe

⚠ Reproductive toxicity in animals

Sodium — Limited Evidence

⚠ Hypertension

⚠ Fluid retention

Silicon — Generally Safe

⚠ Very low toxicity

Calcium — Conditionally Safe

⚠ Cardiovascular risk debated >1,000 mg/day

⚠ Kidney stones

Magnesium — Use with Caution

⚠ Diarrhea (especially oxide)

⚠ Accumulates in renal impairment

Xylitol — High risk

⚠ GI distress (gas, bloating, diarrhea) dose-dependent

⚠ Cardiovascular risk: 2023 Cleveland Clinic study linked xylitol to increased thrombotic events

4 Label claims

• All Other

• Structure/Function

5 Data source

DSLD ID34898

Full labelView at NIH DSLD →

SourceOffice of Dietary Supplements, NIH

Market statusOn market

Entry date2014-07-25

6 More from Mannatech

View Mannatech Safety Scorecard → 33 products

Advanced Ambrose Advanced Ambrotose Complex Powder Advanced Ambrotose Complex Powder Advanced Ambrotose Complex Powder AmbroStart Orange Flavored Ambrotose AO

7 Cite this page

Vancouver

Pkhakadze G. PLUS — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Aug 27]. Available from: https://academy.gmj.ge/products/plus-34898/

CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.

Analyzed by SupplementIndex

PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD

Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG