1 Product identity

Ingredient risk

Contains a high-risk ingredient

OSP

Name: OSP
Brand: Mannatech

BrandMannatech→Other Combinations Unknown 81 ingredients 1 high-risk 7 caution DSLD #40682

Net contents: 56 Packet(s)

Target: Adults and Children 4 years and above

DSLD entry: 2014-12-29

2 Ingredients (81)

IngredientGroupSafety

CaloriesCalories—

Total CarbohydratesCarbohydrate—

Dietary FiberFiber (unspecified)—

ProteinProtein (unspecified)—

Vitamin AVitamin A (unspecified)—

Vitamin CVitamin C (unspecified)—

Vitamin DVitamin DUse with Caution

Vitamin EVitamin EConditionally Safe

ThiaminVitamin B1 (Thiamine)Use with Caution

RiboflavinVitamin B2 (Riboflavin)—

NiacinVitamin B3 (Niacin)—

Vitamin B6Vitamin B6 (unspecified)Use with Caution

Folic AcidVitamin B9 (folic acid) —

Vitamin B12Vitamin B12 (unspecified)Use with Caution

BiotinVitamin B7 (biotin)—

Pantothenic AcidVitamin B5 (Pantothenic Acid)—

CalciumCalciumConditionally Safe

IronIronUse with Caution

IodineIodineConditionally Safe

MagnesiumMagnesiumUse with Caution

ZincZincUse with Caution

SeleniumSeleniumConditionally Safe

CopperCopperConditionally Safe

ManganeseManganeseConditionally Safe

ChromiumChromiumConditionally Safe

MolybdenumMolybdenumGenerally Safe

SodiumSodiumConditionally Safe

Ambrotose ComplexTBD—

Gum ArabicAcacia—

Xanthan GumXanthan Gum—

Gum TragacanthTragacanth—

Ghatti GumGhatti—

Aloe veraAloe—

ArabinogalactanArabinogalactan—

Wild Yam extractWild YamConditionally Safe

L-Glutamic AcidGlutamic Acid—

GlycineGlycineGenerally Safe

L-LysineLysine—

L-ArginineArginine—

MTech AO Blend(R)Proprietary Blend (Combination)—

Quercetin DihydrateQuercetinConditionally Safe

Grape skin extractGrape —

Green Tea extractGreen Tea—

Australian Bush PlumBillygoat plum—

Beta-SitosterolBeta Sitosterol—

RutinRutin—

BoronBoronConditionally Safe

VanadiumVanadiumLimited Evidence

Optimal Support Phyto-BlendBlend (Herb/Botanical)—

Broccoli concentrateBroccoli—

Cranberry juice concentratecranberry—

Grape skin extractGrape —

BroccoliBroccoli—

Brussels SproutBrussel Sprout—

CabbageCabbage—

CarrotCarrot —

CauliflowerCauliflower —

GarlicGarlic—

KaleKale—

Oniononion—

TomatoTomato—

TurnipTurnip—

PapayaPapaya—

Pineapple juice powderPineapple—

Dicalcium PhosphateCalciumConditionally Safe

Microcrystallline CelluloseCellulose—

MustardMustard (unspecified)—

Red AlgaeRed Algae—

Hydroxpropyl MethylcelluloseHypromellose—

Croscarmellose SodiumCroscarmellose Sodium—

Stearic AcidStearic Acid—

Silicon DioxideSiliconGenerally Safe

Citric AcidCitric Acid—

Magnesium StearateMagnesiumUse with Caution

DextrinDextrin—

Calcium CarbonateCalciumConditionally Safe

Dextrose MonohydrateGlucose—

Soy Lecithinlecithin—

Sodium CarboxymethylcelluloseCarboxy Methyl Cellulose—

Medium Chain TriglyceridesMedium chain triglycerides (MCT)—

XylitolXylitolHigh risk

Ingredient amounts require the full DSLD label. View full label at NIH DSLD →

⛔ High-risk ingredient — documented serious harm

Xylitol — Dog owner not warned about xylitol toxicity — potentially fatal to dogs [1]

⚠️ Use with caution — restricted in some markets

Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]

Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…

Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…

Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…

Iron — Iron supplementation in iron-replete patients may increase cardiovascular and cancer risk — always document deficiency before prescribing [1].

Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].

Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].

3 Safety cross-reference

Vitamin A — Limited Evidence

⚠ Teratogenic at high doses

⚠ Hepatotoxic with chronic excess

Vitamin C — Limited Evidence

⚠ GI distress at high doses

⚠ Kidney stones risk >1g/day

Vitamin D — Use with Caution

⚠ Hypercalcemia at >10,000 IU/day

⚠ Vascular calcification risk

Vitamin E — Conditionally Safe

⚠ Increased bleeding risk

⚠ All-cause mortality at >400 IU/day

Thiamin — Use with Caution

Riboflavin — Limited Evidence

⚠ Harmless yellow urine

Niacin — Limited Evidence

⚠ Flushing at >50 mg

⚠ Hepatotoxicity at high doses

Vitamin B6 — Use with Caution

Vitamin B12 — Use with Caution

Biotin — Limited Evidence

⚠ Interferes with troponin and thyroid lab assays

Pantothenic Acid — Limited Evidence

⚠ Diarrhea at very high doses

Calcium — Conditionally Safe

⚠ Cardiovascular risk debated >1,000 mg/day

⚠ Kidney stones

Iron — Use with Caution

⚠ GI upset, constipation

⚠ Fatal toxicity in children

Iodine — Conditionally Safe

⚠ Thyroid dysfunction at excess

⚠ Kelp: variable content

Magnesium — Use with Caution

⚠ Diarrhea (especially oxide)

⚠ Accumulates in renal impairment

Zinc — Use with Caution

⚠ Copper deficiency at >40 mg/day

⚠ Nausea, metallic taste

Selenium — Conditionally Safe

⚠ Selenosis >400 mcg

⚠ Diabetes risk at high doses

Copper — Conditionally Safe

⚠ Hepatotoxicity at high doses

Manganese — Conditionally Safe

⚠ Neurotoxicity with chronic excess

Chromium — Conditionally Safe

⚠ Hypoglycemia with diabetes meds

⚠ Rare renal/hepatic toxicity

Molybdenum — Generally Safe

⚠ Very low toxicity

Sodium — Conditionally Safe

⚠ Hypertension

⚠ Fluid retention

Wild Yam — Conditionally Safe

⚠ Does NOT convert to progesterone in body despite marketing claims

⚠ Estrogenic effects

Glycine — Generally Safe

⚠ Well tolerated

L-Lysine — Limited Evidence

⚠ GI discomfort at high doses

⚠ May increase calcium absorption

L-Arginine — Limited Evidence

⚠ Hypotension

⚠ May worsen herpes outbreaks

Quercetin — Conditionally Safe

⚠ Inhibits CYP3A4

⚠ Affects cyclosporine levels

Green Tea Extract — Limited Evidence

⚠ HEPATOTOXICITY >800 mg EGCG

⚠ Iron absorption inhibition

Boron — Conditionally Safe

⚠ Reproductive toxicity in animals

Vanadium — Limited Evidence

⚠ GI toxicity: nausea, vomiting, diarrhea

⚠ Green tongue

Silicon — Generally Safe

⚠ Very low toxicity

Xylitol — High risk

⚠ GI distress (gas, bloating, diarrhea) dose-dependent

⚠ Cardiovascular risk: 2023 Cleveland Clinic study linked xylitol to increased thrombotic events

4 Label claims

• All Other

• Structure/Function

5 Data source

DSLD ID40682

Full labelView at NIH DSLD →

SourceOffice of Dietary Supplements, NIH

Market statusOn market

Entry date2014-12-29

6 More from Mannatech

View Mannatech Safety Scorecard → 33 products

Advanced Ambrose Advanced Ambrotose Complex Powder Advanced Ambrotose Complex Powder Advanced Ambrotose Complex Powder AmbroStart Orange Flavored Ambrotose AO

7 Cite this page

Vancouver

Pkhakadze G. OSP — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Aug 27]. Available from: https://academy.gmj.ge/products/osp-40682/

CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.

Analyzed by SupplementIndex

PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD

Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG