1 Product identity
Ingredient risk
Contains a high-risk ingredient
Opti-Men
BrandON Optimum Nutrition→Other Combinations Tablet or Pill 86 ingredients 1 high-risk 6 caution DSLD #39489Net contents: 90 Tablet(s)
Target: Adults and Children 4 years and above
DSLD entry: 2014-11-25
2 Ingredients (86)
IngredientGroupSafety
Amino Men BlendBlend—
L-ValineValine—
L-IsoleucineIsoleucine—
Alpha-Glucan OligosaccharideAlpha Glucans—
L-ThreonineTHREONINE—
Phyto Men BlendBlend (Combination)—
Green Tea powderGreen Tea—
Hesperidin ComplexBlend (non-nutrient/non-botanical)—
deodorized Garlic powderGarlic—
Fruit BlendBlend (Herb/Botanical)—
Orange powderOrange (unspecified)—
Pineapple powderPineapple—
Apple powderApple—
Grape powderGrape —
Blueberry powderBlueberry—
Cranberry powdercranberry—
Papaya powderPapaya—
Black Currant powderBlack Currant—
Kiwi powderKiwi—
Vegetable BlendBlend (Herb/Botanical)—
Carrot powderCarrot —
Cauliflower powderCauliflower —
Kale powderKale—
Brussels Sprouts powderBrussel Sprout—
Broccoli powderBroccoli—
Viri Men BlendBlend (Herb/Botanical)—
Nettles powdered extractNettle (unspecified)—
Pumpkin extractPumpkin—
Raw Oyster concentrateOyster—
Enzyme BlendBlend (non-nutrient/non-botanical)—
Alpha-AmylaseAmylase—
LipaseLipase—
Alpha Lipoic AcidAlpha Lipoic Acid—
PABAPABA—
LycopeneLycopene—
Alpha CaroteneAlpha-carotene—
CryptoxanthinCryptoxanthin—
ZeaxanthinZeaxanthin—
Microcrystalline CelluloseCellulose—
Stearic AcidStearic Acid—
Ingredient amounts require the full DSLD label. View full label at NIH DSLD →
⛔ High-risk ingredient — documented serious harm
Inositol — GDM prevention — 4 g/day from first trimester in high-risk women [2]
⚠️ Use with caution — restricted in some markets
Vitamin D — Granulomatous diseases (sarcoidosis, TB) — unregulated extra-renal CYP27B1 can cause life-threatening hypercalcemia even at standard doses [2][21]
Thiamin — Wernicke encephalopathy: classic triad (confusion, ophthalmoplegia, ataxia) is present in only 16% of cases — any ONE element in an at-risk patie…
Vitamin B6 — Sensory neuropathy from chronic high-dose B6 (>200 mg/day) — presents as numbness, ataxia. Can be irreversible. Often self-prescribed by patients…
Vitamin B12 — Nitrous oxide anesthesia in subclinically B12-deficient patients can precipitate acute combined degeneration — always check B12 before elective p…
Magnesium — Severe deficiency (<0.50 mmol/L) causes secondary hypocalcemia and hypokalemia that will not correct until magnesium is repleted first [1].
Zinc — Chronic zinc >40 mg/day without copper causes copper deficiency: anemia, neutropenia, myeloneuropathy [1].
3 Safety cross-reference
Vitamin A — Limited Evidence
⚠ Teratogenic at high doses
⚠ Hepatotoxic with chronic excess
Vitamin C — Generally Safe
⚠ GI distress at high doses
⚠ Kidney stones risk >1g/day
Vitamin D — Use with Caution
⚠ Hypercalcemia at >10,000 IU/day
⚠ Vascular calcification risk
Vitamin E — Conditionally Safe
⚠ Increased bleeding risk
⚠ All-cause mortality at >400 IU/day
Vitamin K — Limited Evidence
⚠ Critical interaction with warfarin
Thiamin — Use with Caution
⚠ Very low toxicity
Riboflavin — Generally Safe
⚠ Harmless yellow urine
Niacin — Conditionally Safe
⚠ Flushing at >50 mg
⚠ Hepatotoxicity at high doses
Vitamin B6 — Use with Caution
Folate — Conditionally Safe
⚠ May mask B12 deficiency
⚠ Colorectal cancer risk debated
Vitamin B12 — Use with Caution
Biotin — Generally Safe
⚠ Interferes with troponin and thyroid lab assays
Pantothenic Acid — Limited Evidence
⚠ Diarrhea at very high doses
Calcium — Conditionally Safe
⚠ Cardiovascular risk debated >1,000 mg/day
⚠ Kidney stones
Iodine — Conditionally Safe
⚠ Thyroid dysfunction at excess
⚠ Kelp: variable content
Magnesium — Use with Caution
⚠ Diarrhea (especially oxide)
⚠ Accumulates in renal impairment
Zinc — Use with Caution
⚠ Copper deficiency at >40 mg/day
⚠ Nausea, metallic taste
Selenium — Conditionally Safe
⚠ Selenosis >400 mcg
⚠ Diabetes risk at high doses
Copper — Conditionally Safe
⚠ Hepatotoxicity at high doses
Manganese — Conditionally Safe
⚠ Neurotoxicity with chronic excess
Chromium — Conditionally Safe
⚠ Hypoglycemia with diabetes meds
⚠ Rare renal/hepatic toxicity
Molybdenum — Generally Safe
⚠ Very low toxicity
L-Arginine — Limited Evidence
⚠ Hypotension
⚠ May worsen herpes outbreaks
L-Glutamine — Conditionally Safe
⚠ Hepatic encephalopathy risk
⚠ May elevate ammonia
L-Leucine — Limited Evidence
⚠ May worsen pellagra
⚠ High doses may impair glucose metabolism
Chloride — Limited Evidence
⚠ Co-ingested with sodium
Grape Seed Extract — Limited Evidence
⚠ Antiplatelet effect
⚠ May interact with anticoagulants
Elderberry — Limited Evidence
⚠ Raw berries: cyanogenic glycosides
⚠ Cytokine storm concern
bilberry — Generally Safe
⚠ May increase bleeding risk at high doses
⚠ May lower blood glucose
Wild Yam — Conditionally Safe
⚠ Does NOT convert to progesterone in body despite marketing claims
⚠ Estrogenic effects
NAC — Limited Evidence
⚠ GI upset
⚠ Rare bronchospasm
Saw Palmetto — Generally Safe
⚠ Anti-androgenic
⚠ May affect PSA
Damiana — Conditionally Safe
⚠ May lower blood glucose
⚠ Hallucinations at very high doses
Panax Ginseng — Limited Evidence
⚠ Insomnia
⚠ Estrogenic effects
Ginkgo Biloba — Limited Evidence
⚠ BLEEDING RISK
⚠ Seizures (ginkgotoxin)
Papain — Conditionally Safe
⚠ Allergic reactions
⚠ Increased bleeding risk
Bromelain — Conditionally Safe
⚠ Increased bleeding risk
⚠ GI upset
Choline — Generally Safe
⚠ Fishy odor at high doses
Inositol — High risk
⚠ GI disturbance at high doses (>12 g)
⚠ May lower blood glucose
Boron — Conditionally Safe
⚠ Reproductive toxicity in animals
Lutein — Generally Safe
⚠ Harmless skin yellowing at very high doses
Vanadium — Limited Evidence
⚠ GI toxicity: nausea, vomiting, diarrhea
⚠ Green tongue
Sodium — Limited Evidence
⚠ Hypertension
⚠ Fluid retention
GLA — Limited Evidence
⚠ May lower seizure threshold
⚠ Borage oil: hepatotoxic unless PA-free
Silicon — Generally Safe
⚠ Very low toxicity
4 Label claims
• All Other
• Structure/Function
5 Data source
DSLD ID39489
Full labelView at NIH DSLD →
SourceOffice of Dietary Supplements, NIH
Market statusOn market
Entry date2014-11-25
6 More from ON Optimum Nutrition
View ON Optimum Nutrition Safety Scorecard → 88 products
Banana Cream PieBCAA 1000 Caps 1,000 mgBeta-Alanine Powder UnflavoredCLA 750 mgCLA 750 mgCreatine 2500 Caps7 Cite this page
Vancouver
Pkhakadze G. Opti-Men — product analysis [Internet]. Tbilisi: Public Health Institute of Georgia; 2026 [cited 2026 Aug 27]. Available from: https://academy.gmj.ge/products/dsld-39489/
CC BY 4.0. Product data from NIH DSLD; safety analysis by SupplementIndex.
GP
Analyzed by SupplementIndex
PHIG · Editor-in-Chief: Prof. Giorgi Pkhakadze, MD, MPH, PhD
Product data sourced from the NIH Dietary Supplement Label Database (DSLD). Safety cross-referencing by SupplementIndex. This analysis is for informational purposes only. For corrections: info@accreditation.ge.
Publisher: PHIG
Publisher: PHIG