✓ No active regulatory warningsFDA MedWatch, EMA EudraVigilance, WHO VigiBase, WADA Prohibited List · 2026-05-29
Updated: 2026-05-29 · v2.0 · Prof. G. Pkhakadze, MD, MPH, PhDCiteEditorial
📰Read the full L-Proline evidence review on GMJ News →Complete clinical article, references and updates on news.gmj.ge. This page is the structured safety summary.
1
Safe
L-Proline
L-Proline
Generally SafeLimitedAmino Acids
RDA
Typical 500–1,000 mg
Target
N/A
Upper limit
No UL
Products
3
Dosage by population group — reference
🔗 Best with: L-Lysine, Vitamin C, Collagen Peptides✅ USP Verified, NSF Certified for Sport, Informed Sport
⚠ Collagen peptides > isolated proline [2]
⚠ Proline + lysine + vitamin C = collagen synthesis triad [1]
ℹ️ Not obtained from food. Obtained as part of dietary protein (and made by the body) rather than tracked toward a daily target.
🔬 Lab interpreter
ℹ️ No validated blood test. There is no established laboratory test to assess status or guide dosing for this ingredient. Clinical response and symptoms are the practical guide.
⚕ For professionals — confirm ranges against your local laboratory.
Clinical verdict
Proline is a key collagen amino acid but isolated supplementation has minimal evidence. Collagen peptides (5–10 g) provide proline + glycine + hydroxyproline + bioactive peptides — better choice [1] [2].
1 How much do I need?
👤 Adults: Specific dosage data under clinical review
👴 Elderly: Specific dosage data under clinical review
🤰 Pregnancy: See guidance
Food amino acid. Safe [1].
👦 Pediatric: See guidance
Food AA [1].
🏃 Athletes: Standard dose
⚖️ Obesity: Standard dose
Fat-soluble compounds may require dose adjustment in obesity.
🩺 Renal: Consult specialist
Dose adjustment may be needed in renal impairment.
🌱 Vegan: Standard dose

How to take

🍽 Timing: Any [1].
💊 With food: With vitamin C [1].
🚫 Avoid: N/A [1].
2 Which form?
FormBioavailabilityVeganCost
['L-Proline capsules', 'common', '500–1,000 mg [1].']StandardCheck label
3 Common questions
Proline vs collagen peptides? ▼
Collagen peptides provide proline PLUS glycine, hydroxyproline, and bioactive peptides. More practical and better-evidenced than isolated proline [2].
4 Clinical evidence

Strong

Proline is essential for collagen structure: basic biochemistry [1]. HIGH

Moderate

Collagen synthesis requires proline + vitamin C: well-established [1]. MODERATE

Insufficient

Isolated proline supplementation for any clinical outcome [2]. Collagen peptides are better-evidenced for skin/joint [2]. LOW
5 Safety, toxicity & adverse events

Relative

⚠ Generally well tolerated; high-dose long-term data limited
⚠ Pregnancy and lactation — food amounts safe; supplemental data limited
6 Interactions

Supplement synergies

Vitamin C + Lysine + Collagen · Standard doses
Complete collagen support [1].
7 Regulatory
United States: GRAS. Supplement [1].
8 US supplement products
3
on-market products containing L-Proline (NIH DSLD)

Brands carrying L-Proline (1)

Click a brand to see its L-Proline products.
Or browse all 3 products in one list →
9 Frequently paired with
Hyaluronic Acid 3 sharedSodium 3 sharedGrape Seed Extract 2 sharedL-Lysine 1 sharedVitamin A 1 shared
L-Proline vs L-LysineL-Proline vs Vitamin C
10 Cite this page
Vancouver: Pkhakadze G. L-Proline — safety profile [Internet]. Tbilisi: PHIG; 2026 [cited 2026 Aug 15]. Available from: https://supplement.ge/ingredients/l-proline/
APA 7th: Pkhakadze, G. (2026). L-Proline — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/l-proline/
📋 Editorial information
Author: Prof. G. Pkhakadze, MD, MPH, PhD
Affiliation: David Tvildiani Medical University (DTMU)
First published: January 2026
Last reviewed: 2026-05-29
Next review: February 2027
References: 2 cited sources
COI: SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.
Process: Systematic literature review
📄 License & reuse
Published under Creative Commons Attribution 4.0 International (CC BY 4.0). You may share and adapt for any purpose with attribution.
Pkhakadze G. "L-Proline — Safety Profile." SupplementIndex, PHIG, 2026. https://supplement.ge/ingredients/l-proline/ CC BY 4.0.
GP
Prof. G. Pkhakadze, MD, MPH, PhD
Professor of Public Health · Head of Department, DTMU
Editor-in-Chief, Georgian Medical Journal (ISSN 3088-4322)
Chair, Public Health Institute of Georgia · UEMS Public Health Section
Educational and public health purposes. CC BY 4.0. Consult your healthcare provider before starting any supplement. Corrections: info@accreditation.ge. Publisher: PHIG