CAU

Graviola Leaf

Annona muricata
Use with Caution V1 Verified Herbs and Botanicals
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PubMed Studies
880
About

Soursop leaf with annonacin and acetogenins. Anti-cancer and antiparasitic properties. Controversial due to neurotoxicity risk.

How it works (mechanism of action)

Contains bioactive phytochemicals (alkaloids, terpenoids, polyphenols, or glycosides) modulating cellular signalling pathways. Primary mechanisms include enzyme inhibition, receptor modulation, and transcription factor activation relevant to documented clinical indications.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralPossibly unsafeNot established
PregnancyPossibly unsafeNot established
ElderlyPossibly unsafeNot established
🚫 Contraindications & Warnings

Neurotoxicity: annonacin associated with atypical Parkinson disease. Antihypertensive interaction.

🏷️ Other Names
Annona muricata
Updated: 2026-03-31
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