SAFE

Glucosamine HCl

Glucosamine hydrochloride
Possibly Safe V2 Verified Specialty Bioactives
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PubMed Studies
6
PubChem CID
About

Hydrochloride salt form of glucosamine. Less studied than sulfate form — GAIT trial (NIH) used HCl form and showed less benefit than European sulfate studies. Same shellfish-derived source concerns.

How it works (mechanism of action)

Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralPossibly safeNot established
PregnancyPossibly safeNot established
ElderlyPossibly safeNot established
🚫 Contraindications & Warnings

SHELLFISH ALLERGY: same caution as glucosamine sulfate. Warfarin interaction applies. Blood glucose monitoring in diabetes. Less evidence than sulfate form for OA.

🇪🇺 EU Health Claims Status
Art.13(1)
✓ Authorised
Non-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
🏷️ Other Names
Glucosamine hydrochloride
Updated: 2026-04-11
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