SAFE
Globe Artichoke Extract
Cynara scolymus 5% cynarin capsules
Likely Safe
V1 Verified
Liver Herbs
PubMed Studies
1,800
About
Standardised artichoke leaf for liver support, bile flow, and cholesterol reduction. IBS meta-analysis positive.
How it works (mechanism of action)
Provides hepatoprotective effects via antioxidant enzyme induction (GPx, SOD), NF-kB suppression reducing hepatocyte apoptosis, and cytochrome P450 modulation. Choleretic action stimulates bile flow and composition benefiting lipid digestion and hepatic detoxification.
📊 Effectiveness
Dyspepsia and bloating
Evidence Grade A · 6 studies · n=240 · Meta-analysis available
Cholesterol
Evidence Grade B · 12 studies · n=1,200
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
Gallstones: use with caution. Allergy to Asteraceae.
🏷️ Other Names
Cynara scolymus 5% cynarin capsules