⚠️
Major drug interaction. This ingredient has clinically significant drug interactions. See Drug Interactions below before use.
SAFE

Garlic Aged Extract

Aged garlic extract (Kyolic)
Likely Safe V1 Verified Immune Herbs
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PubMed Studies
2,200
About

Kyolic aged garlic extract with S-allylcysteine for immune function, cardiovascular health, and antioxidant protection. Odour-free.

How it works (mechanism of action)

Activates innate immune cells (macrophages, NK cells, neutrophils) via pattern recognition receptor stimulation. Modulates adaptive immune responses shifting Th1/Th2 balance. Antiviral mechanisms involve direct interference with viral entry, replication, or assembly.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralLikely safeNot established
PregnancyLikely safeNot established
ElderlyLikely safeNot established
🚫 Contraindications & Warnings

Anticoagulant interaction. Drug interaction with saquinavir. Generally well tolerated.

💊 Drug Interactions (5)
🔴 Saquinavir
Major
HIV Protease inhibitors
Management: AVOID garlic supplements with saquinavir. Potentially reduces HIV treatment efficacy.
🔴 Saquinavir / HIV PIs
Major
Antiretrovirals
Management: Contraindicated with saquinavir and likely other HIV protease inhibitors.
🟡 Warfarin
Moderate
Anticoagulants
Management: Monitor INR with high-dose garlic supplementation. Discontinue 2 weeks before surgery.
🟡 Aspirin / Clopidogrel
Moderate
Antiplatelet drugs
Management: Use caution. Risk of excessive bleeding especially perioperatively.
⚪ ACE inhibitors
Minor
Antihypertensives
Management: Monitor BP. Often used intentionally — may enhance antihypertensive therapy.
🏷️ Other Names
Aged garlic extract (Kyolic)
Updated: 2026-03-31
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