PubMed Studies
280
About
Fringe tree bark contains saponins with cholagogue, laxative, and liver-protective effects. Used for cholecystitis and liver congestion.
How it works (mechanism of action)
Provides hepatoprotective effects via antioxidant enzyme induction (GPx, SOD), NF-kB suppression reducing hepatocyte apoptosis, and cytochrome P450 modulation. Choleretic action stimulates bile flow and composition benefiting lipid digestion and hepatic detoxification.
👥 Safety by Population
🚫 Contraindications & Warnings
Pregnancy: insufficient data. Limited clinical data.
🏷️ Other Names
Chionanthus virginicus