SAFE

Epigallocatechin

Epigallocatechin (EGC)
Likely Safe V1 Verified Polyphenols
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PubMed Studies
239
PubChem CID
About

EGC is a catechin from green tea. Along with EGCG, provides the majority of green tea's health benefits.

How it works (mechanism of action)

Acts as direct free radical scavenger and indirect antioxidant via Nrf2/ARE pathway activation. Modulates inflammatory signalling via NF-kB and AP-1 inhibition. Interacts with kinase pathways (MAPK, PI3K/Akt, mTOR) and epigenetic regulators relevant to anti-ageing and disease prevention.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralLikely safeNot established
PregnancyLikely safeNot established
ElderlyLikely safeNot established
🚫 Contraindications & Warnings

Very safe. Different from EGCG. Combined in green tea extracts.

🇪🇺 EU Health Claims Status
Art.13(1)
✓ Authorised
Non-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
🏷️ Other Names
Epigallocatechin (EGC)
Updated: 2026-04-11
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