SAFE
Dimethicone
Polydimethylsiloxane (PDMS)
Possibly Safe
V2 Verified
Excipients & Additives
PubMed Studies
37
About
Silicone polymer used as antifoaming agent, lubricant, and skin protectant in cosmetics and pharmaceuticals. Poorly absorbed from GI tract. Very wide safety margin.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
👥 Safety by Population
🚫 Contraindications & Warnings
Generally very safe. Minimal systemic absorption. Inert. Used in infant preparations. No significant safety concerns at typical excipient quantities.
🏷️ Other Names
Polydimethylsiloxane (PDMS)