SAFE
Dihydromyricetin
DHM (Hovenia dulcis extract)
Possibly Safe
V1 Verified
Nootropics
PubMed Studies
2
PubChem CID
About
GABA-A modulator from Japanese raisin tree. Used for alcohol metabolism, liver protection, and anxiety.
How it works (mechanism of action)
Enhances cognitive function via cholinergic system activation, cerebrovascular blood flow improvement, or neuroplasticity enhancement via BDNF/NGF upregulation. Neuroprotective mechanisms include antioxidant activity and reduction of excitotoxic glutamate signalling.
📊 Effectiveness
Alcohol metabolism support
Evidence Grade B · 8 studies · n=580
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
GABAergic medication interaction. Pregnancy: insufficient data. Generally well tolerated.
🏷️ Other Names
DHM (Hovenia dulcis extract)