Diethanolamine
Ethanolamine compound used as pH adjuster and emulsifier in cosmetics and some pharmaceutical excipients. Reacts with nitrosating agents to form N-nitrosodiethanolamine (NDELA) — a potent carcinogen. FDA has warned against use of DEA-containing products. IARC Group 2B carcinogen.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
IARC Group 2B carcinogen (possibly carcinogenic to humans) via N-nitroso formation. FDA public health advisory against cosmetic products containing DEA. Avoid in oral supplements entirely. Prohibited in EU cosmetics as a precautionary measure. No acceptable intake for mutagenic carcinogens.