SAFE
Di Long
Pheretima aspergillum (Earthworm/Di Long)
Possibly Safe
V1 Verified
TCM Herbs
PubMed Studies
680
About
Di Long (earthworm) contains fibrinolytic enzymes (lumbrokinase) and adenosine with anticoagulant, antihypertensive, and bronchodilatory effects.
How it works (mechanism of action)
Acts via multiple pharmacodynamic mechanisms consistent with Traditional Chinese Medicine polypharmacology. Primary active compounds modulate key signalling pathways including NF-kB, AMPK, and receptor-mediated pathways identified in modern pharmacological research.
📊 Effectiveness
Hypertension and thrombosis
Evidence Grade B · 8 studies · n=680
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
Anticoagulant interaction: significant. Blood pressure interaction. Allergy to earthworm proteins.
🏷️ Other Names
Pheretima aspergillum (Earthworm/Di Long)