✓ No active regulatory warningsFDA MedWatch, EMA EudraVigilance, WHO VigiBase, WADA Prohibited List · 2026-05-29
📰Read the full D-Aspartic Acid evidence review on GMJ News →Complete clinical article, references and updates on news.gmj.ge. This page is the structured safety summary.⚠ Follow-up studies NEGATIVE in trained men [2]
⚠ One study showed testosterone DECREASE [2]
⚠ Same hype-then-failure pattern as tribulus [1] [2]
ℹ️ Not obtained from food. Not applicable as a daily target — obtained as part of dietary protein rather than tracked individually.
🔬 Lab interpreter
Recommended test
Testosterone
Testosterone
Reference range / target
No change expected in trained men
Full lab monitoring ↓No change expected in trained men
⚕ For professionals — confirm ranges against your local laboratory.
Clinical verdict
1 How much do I need?
👤 Adults: Specific dosage data under clinical review
👴 Elderly: Specific dosage data under clinical review
🤰 Pregnancy: See guidance
AVOID [1].
👦 Pediatric: See guidance
Not appropriate [1].
🏃 Athletes: Standard dose
⚖️ Obesity: Standard dose
Fat-soluble compounds may require dose adjustment in obesity.
🩺 Renal: Consult specialist
Dose adjustment may be needed in renal impairment.
🌱 Vegan: Standard dose
How to take
🍽 Timing: NOT recommended [2].
💊 With food: N/A [2].
🚫 Avoid: Expecting testosterone boost in trained men [2].
2 Which form?
| Form | Bioavailability | Vegan | Cost |
|---|---|---|---|
| ['D-Aspartic acid (sodium salt)', 'common', '2–3 g/day [1].'] | Standard | Check label |
3 Common questions
4 Clinical evidence
Strong
Topo 2009: 42% T increase in 12 days (small study, untrained men) [1]. Subsequent studies in trained men: NO significant T increase [2]. HIGH
Moderate
LH stimulation: confirmed acutely [1]. MODERATE
Insufficient
5 Safety, toxicity & adverse events
Relative
⚠ Hormone-sensitive conditions — affects testosterone signaling
⚠ Effects often not sustained and may reverse with continued use
⚠ Pregnancy and lactation — avoid
⚠ Psychiatric conditions — glutamatergic activity, theoretical caution
🚩 Red flags
● Patient buying DAA for testosterone — follow-up studies negative [2]
6 Interactions
7 Regulatory
United States: Dietary supplement [1].
8 US supplement products
33
on-market products containing D-Aspartic Acid (NIH DSLD)
Brands carrying D-Aspartic Acid (25)
Click a brand to see its D-Aspartic Acid products.
9 Frequently paired with
10 Cite this page
Vancouver: Pkhakadze G. D-Aspartic Acid — safety profile [Internet]. Tbilisi: PHIG; 2026 [cited 2026 Oct 10]. Available from: https://supplement.ge/ingredients/d-aspartic-acid/
APA 7th: Pkhakadze, G. (2026). D-Aspartic Acid — Safety profile. Public Health Institute of Georgia. https://supplement.ge/ingredients/d-aspartic-acid/
📋 Editorial information
Author: Prof. G. Pkhakadze, MD, MPH, PhD
Institution: Public Health Institute of Georgia (PHIG)
Affiliation: David Tvildiani Medical University (DTMU)
First published: January 2026
Last reviewed: 2026-05-29
Next review: April 2027
References: 2 cited sources
COI: SupplementIndex receives no funding from supplement manufacturers. All content independently authored by PHIG.
Process: Systematic literature review
📄 License & reuse
Published under Creative Commons Attribution 4.0 International (CC BY 4.0). You may share and adapt for any purpose with attribution.
Pkhakadze G. "D-Aspartic Acid — Safety Profile." SupplementIndex, PHIG, 2026. https://supplement.ge/ingredients/d-aspartic-acid/ CC BY 4.0.
GP
Prof. G. Pkhakadze, MD, MPH, PhD
Professor of Public Health · Head of Department, DTMU
Editor-in-Chief, Georgian Medical Journal (ISSN 3088-4322)
Chair, Public Health Institute of Georgia · UEMS Public Health Section
Educational and public health purposes. CC BY 4.0. Consult your healthcare provider before starting any supplement. Corrections: info@accreditation.ge. Publisher: PHIG