⛔
Regulatory ban. This ingredient is banned or restricted in one or more countries. See Regulatory Status below.
SAFE

Curcumin

Curcumin I (diferuloylmethane) from Curcuma longa
Possibly Safe V2 Verified Specialty Bioactives
Scan supplement →
PubMed Studies
562
PubChem CID
About

Primary curcuminoid from turmeric. Anti-inflammatory (NF-κB and COX-2 inhibition), antioxidant, and potential anti-cancer properties. Poor oral bioavailability without formulation technology. Very large number of clinical trials.

How it works (mechanism of action)

Potent NF-kB inhibitor (blocking IKK phosphorylation of IkBa). Inhibits COX-2 and 5-lipoxygenase. Activates Nrf2 and HO-1 antioxidant pathway. Inhibits VEGF-mediated angiogenesis. Chelates redox-active metals. Poor bioavailability requires piperine or phospholipid complex.

⚖️ Regulatory Status
⛔
FR — Banned
ANSES recommended ban of kava following hepatotoxicity signals from nutrivigilance system.
⛔
NZ — Banned
Medsafe NZ — ephedrine alkaloid supplements banned following FDA and TGA action.
⛔
NL — Banned
NVWA prohibition (2004).
⛔
MY — Banned
NPRA Malaysia — ephedra and ephedrine alkaloid supplements prohibited.
⛔
SA — Banned
SFDA Saudi Arabia — ephedra and ephedrine alkaloid supplements prohibited. Controlled as prescription drug.
⛔
SE — Banned
Livsmedelsverket Sweden prohibition aligned with EU Directive 2002/46/EC.
⛔
IT — Banned
Italian Ministry of Health — ephedra and ephedrine alkaloid supplements prohibited under EU Directive 2002/46/EC.
⛔
AE — Banned
UAE MOH prohibition — ephedra supplements banned. Ephedrine controlled as pharmaceutical.
⛔
SG — Banned
HSA Singapore prohibition (2004) — ephedra alkaloid supplements prohibited.
⛔
ID — Banned
BPOM Indonesia — ephedra and ephedrine alkaloid supplements prohibited.
⛔
PH — Banned
FDA Philippines — ephedra and ephedrine alkaloid-containing food supplements banned following international regulatory action.
⛔
PL — Banned
GIS Poland prohibition aligned with EU Directive 2002/46/EC.
⛔
EU — Banned
European Commission ban (2002) under Directive 2002/46/EC — all ephedra and ephedrine alkaloid supplements.
⛔
ES — Banned
AEMPS Spain prohibition aligned with EU ban on ephedrine alkaloid supplements.
⛔
DK — Banned
Banned (2023) — Danish Veterinary and Food Administration (DVFA). Liver toxicity and thyroid disruption reports. All preparations ordered off market.
⛔
DE — Banned
BfArM banned kava-containing products in Germany in 2002 due to hepatotoxicity risk. Cases of liver failure and death reported.
⛔
US — Banned
FDA ban (2004) — cardiovascular adverse events and deaths. Final rule 21 CFR 119. All ephedrine alkaloids banned from dietary supplements.
⛔
CH — Banned
Swissmedic banned kava in Switzerland due to hepatotoxicity.
⛔
CA — Banned
Health Canada ban (2002) — all ephedra and ephedrine alkaloid-containing supplements.
⛔
BE — Banned
FASFC Belgium prohibition aligned with EU Directive 2002/46/EC.
⛔
AU — Banned
TGA ban (2003) — cardiovascular adverse events. Ephedra alkaloids banned from complementary medicines.
⛔
PT — Banned
ASAE Portugal prohibition aligned with EU ban on ephedrine alkaloid supplements.
⚠️
TH — Restricted
FDA Thailand — ephedrine controlled as pharmaceutical. Not permitted in food supplements.
⚠️
IN — Restricted
CDSCO India (2004) — available only under prescription as pharmaceutical products.
⚠️
TW — Restricted
TFDA Taiwan — ephedrine controlled as pharmaceutical drug. Not permitted as health food ingredient. Products with ephedra claims require pharmaceutical registration.
⚠️
ZA — Restricted
SAHPRA (2004) — Schedule 2; pharmacist oversight required.
⚠️
KR — Restricted
MFDS South Korea (2003) — maximum dose restrictions. Not permitted for weight loss products.
⚠️
JP — Restricted
MHLW Japan (2003) — maximum dose limits; not permitted for weight loss marketing. Ephedrine controlled under pharmaceutical regulations.
⚠️
IE — Restricted
FSAI monitoring (2024) following Danish ban and hepatotoxicity reports. Products without adequate safety data may face withdrawal.
⚠️
HK — Restricted
Department of Health Hong Kong — ephedrine-containing preparations controlled as pharmaceutical products. Not permitted as health food supplements without pharmaceutical registration.
⚠️
GB — Restricted
MHRA (2004) — ephedrine alkaloid supplements restricted. Maximum doses apply under the Medicines Act.
⚠️
CN — Restricted
NMPA China — Ma Huang (ephedra) controlled. Ephedrine alkaloid content restrictions; not permitted for weight loss products. Export of ephedra controlled internationally.
💊
AT — Prescription only
AGES Austria — melatonin classified as prescription-only medicinal product. Not permitted as food supplement.
📊 Effectiveness
Inflammation
Evidence Grade A · 35 studies · n=6,200 · Meta-analysis available
Likely Effective
Osteoarthritis
Evidence Grade A · 22 studies · n=3,800 · Meta-analysis available
Likely Effective
Depression
Evidence Grade B · 12 studies · n=1,200
Possibly Effective

Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralLikely safe8000mg/day
🚫 Contraindications & Warnings

ANTICOAGULANT INTERACTION: potent antiplatelet effects — avoid with warfarin, aspirin, and other anticoagulants/antiplatelets. Drug interactions: CYP3A4 inhibition, P-gp inhibition, CYP1A2 inhibition. Iron chelation — reduces iron absorption. Hepatotoxicity reports (rare, mainly at very high doses). Gallstone disease: stimulates bile secretion — caution. Pregnancy: avoid concentrated extracts (uterine stimulant at high doses).

💊 Drug Interactions (1)
🟡 Anticoagulants
Moderate
Anticoagulant
Management: Monitor INR. Stop 2 weeks before surgery.
Products containing this ingredient (9)
🏷️ Other Names
Turmeric extract Curcuminoids Meriva Turmeric Full Spectrum Curcumin Curcuma longa BCM-95
Updated: 2026-04-11
← All ingredients