SAFE
Cranberry PAC
Cranberry proanthocyanidins (PAC A)
Possibly Safe
V1 Verified
Kidney Herbs
PubMed Studies
2,400
About
Standardised cranberry extract (36mg PAC-A type A) preventing E. coli adherence to urinary epithelium. Evidence for UTI prevention.
How it works (mechanism of action)
Provides diuretic effects via prostaglandin-mediated renal blood flow increase. Anti-inflammatory activity reduces renal tubular inflammation. Antilithic effects may involve urine alkalinisation, citrate excretion, or dissolution of calcium oxalate crystals.
📊 Effectiveness
UTI prevention
Evidence Grade B · 22 studies · n=3,200
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
Warfarin interaction: CYP2C9 inhibition. Generally well tolerated. Does not treat active UTI.
🇪🇺 EU Health Claims Status
Art.13(1)
✓ AuthorisedNon-compliance with the Regulation because on the basis of the scientific evidence assessed, this food is not sufficiently characterised for a scientific assessment of this claimed effect and the claim could not therefore be substantiated.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ AuthorisedNon-compliance with the Regulation because on the basis of the scientific evidence assessed, this food is not sufficiently characterised for a scientific assessment of this claimed effect and the claim could not therefore be substantiated.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ AuthorisedNon-compliance with the Regulation because on the basis of the scientific evidence assessed, the evidence provided is insufficient to substantiate this claimed effect for this food.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ AuthorisedNon-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
🏷️ Other Names
Cranberry proanthocyanidins (PAC A)