SAFE

Coenzyme Q10 Male Fertility

CoQ10 (sperm motility formula)
Likely Safe V1 Verified Mens Health
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PubMed Studies
1,800
About

Improves sperm motility, concentration, and morphology. Used in male fertility protocols.

How it works (mechanism of action)

Inhibits 5-alpha-reductase converting testosterone to DHT or acts as competitive DHT-androgen receptor antagonist. May modulate LH receptor signalling to support testosterone production. Anti-oestrogenic effects possible via aromatase inhibition.

📊 Effectiveness
Sperm motility
Evidence Grade B · 12 studies · n=1,200
Possibly Effective
Heart failure
Evidence Grade B · 13 studies · n=840
Possibly Effective
Exercise performance
Evidence Grade C · 8 studies · n=420
Possibly Effective
Statin myopathy
Evidence Grade B · 9 studies · n=610
Possibly Effective
Blood pressure
Evidence Grade B · 15 studies · n=1,600
Possibly Effective

Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralLikely safe200-300mg/day
🚫 Contraindications & Warnings

Very safe. Minor blood pressure interaction.

💊 Drug Interactions (5)
🟡 Warfarin
Moderate
Anticoagulants
Management: Monitor INR when starting or stopping CoQ10 supplementation.
🟡 Statins
Moderate
HMG-CoA reductase inhibitors
Management: Consider CoQ10 supplementation (100-200mg/day) in patients on statins with muscle symptoms. Does not reduce statin efficacy.
🟡 Doxorubicin
Moderate
Chemotherapy
Management: Discuss with oncologist before use during chemotherapy.
⚪ ACE inhibitors / Beta-blockers
Minor
Antihypertensives
Management: Monitor BP. Meta-analysis shows ~11mmHg SBP reduction. Often used therapeutically.
⚪ Metformin / Insulin
Minor
Antidiabetics
Management: Monitor blood glucose. Generally safe and potentially beneficial.
🇪🇺 EU Health Claims Status
Art.13(1)
✓ Authorised
Non-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
Art.13(1)
✓ Authorised
Non-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
🏷️ Other Names
CoQ10 (sperm motility formula)
Updated: 2026-03-31
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