SAFE
Cholecalciferol
Vitamin D3 (cholecalciferol)
Likely Safe
V2 Verified
Vitamins & Cofactors
PubMed Studies
807
About
Most effective Vitamin D form for raising serum 25(OH)D. Produced in skin by UVB. Used for bone health, immune function, and multiple chronic disease risk reduction.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
👥 Safety by Population
🚫 Contraindications & Warnings
Vitamin D toxicity: hypercalcaemia at very high doses (>10000 IU/day chronic). UL: 4000 IU/day (USA) — many practitioners use higher doses with monitoring. Drug interactions: thiazide diuretics + Vitamin D — hypercalcaemia. Granulomatous disease (sarcoidosis, TB): may cause hypercalcaemia at standard doses. Calcium channel blockers: monitor.
🏷️ Other Names
Vitamin D3 (cholecalciferol)