PubMed Studies
74
PubChem CID
About
Chlorogenic acid is the primary polyphenol in coffee (unroasted) and artichoke. Used for blood sugar, blood pressure, and weight management.
How it works (mechanism of action)
Acts as direct free radical scavenger and indirect antioxidant via Nrf2/ARE pathway activation. Modulates inflammatory signalling via NF-kB and AP-1 inhibition. Interacts with kinase pathways (MAPK, PI3K/Akt, mTOR) and epigenetic regulators relevant to anti-ageing and disease prevention.
👥 Safety by Population
🚫 Contraindications & Warnings
Mildly laxative at high doses. May affect iron absorption. Caffeine-free in supplement form.
🇪🇺 EU Health Claims Status
Art.13(1)
✓ AuthorisedNon-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food has not been substantiated.
Regulation EU 1924/2006 · ART13 1
🏷️ Other Names
Chlorogenic acid