⛔
Regulatory ban. This ingredient is banned or restricted in one or more countries. See Regulatory Status below.
SAFE
Chelating agents
EDTA, citric acid, phytic acid as chelators
Possibly Safe
V2 Verified
Excipients & Additives
PubMed Studies
28
About
General category of mineral-chelating compounds used as antioxidant preservatives and stability enhancers. Reduce free metal ion-catalysed oxidation. Important in liquid supplement formulations.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
⚖️ Regulatory Status
⛔
FR — Banned
Banned by ANSES (2021) — hepatotoxicity confirmed in case reports. All Garcinia cambogia (hydroxycitric acid) supplements prohibited in France.
⚠️
AU — Restricted
TGA monitoring — hepatotoxicity signals. Products subject to adverse event reporting requirements.
⚠️
JP — Restricted
Consumer Affairs Agency Japan advisory (2012) — hepatotoxicity. Mandatory labelling and dose restrictions apply.
👥 Safety by Population
🚫 Contraindications & Warnings
Mineral absorption reduction — take separately from mineral supplements. EDTA: see specific EDTA entry. Phytic acid (IP6): reduces iron, zinc, calcium absorption. Citric acid: generally safe. Separate from mineral supplements by 2+ hours.
🏷️ Other Names
EDTA, citric acid, phytic acid as chelators