SAFE
Chasteberry (Vitex)
Vitex agnus-castus (fruit extract)
Possibly Safe
V2 Verified
Botanicals
PubMed Studies
1,200
About
Mediterranean shrub used for PMS, PMDD, and menopausal symptoms. Dopamine agonist (reduces prolactin), partial opioid agonist. EMA/HMPC monograph.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
👥 Safety by Population
🚫 Contraindications & Warnings
DOPAMINE AGONISM: interacts with dopaminergic drugs — DO NOT combine with levodopa, dopamine agonists, antipsychotics (reduces antidopaminergic effect). Drug interactions: antipsychotics (reduced efficacy), metoclopramide, oral contraceptives. Pregnancy: CONTRAINDICATED (prolactin reduction). Hormonal contraception: potential interaction.
🏷️ Other Names
Vitex agnus-castus (fruit extract)