SAFE
Cat's Claw Anti-inflammatory
Uncaria tomentosa 3% pentacyclic alkaloids
Possibly Safe
V1 Verified
Anti-inflammatory Herbs
PubMed Studies
1,600
About
Cat's claw standardised for anti-inflammatory, anti-arthritis, and immune effects via NF-kB inhibition.
How it works (mechanism of action)
Inhibits key inflammatory enzymes (COX-1/2, 5-LOX) or transcription factors (NF-kB, AP-1) reducing prostaglandin, leukotriene, and cytokine production. Some activate PPAR-gamma nuclear receptor mediating anti-inflammatory gene transcription.
👥 Safety by Population
🚫 Contraindications & Warnings
Autoimmune: avoid. Pregnancy: avoid. Anticoagulant interaction.
🏷️ Other Names
Uncaria tomentosa 3% pentacyclic alkaloids