PubMed Studies
5
About
Cat's claw (Uncaria tomentosa) is a Peruvian vine used for immune support, anti-inflammatory effects, and joint pain. Contains oxindole alkaloids and procyanidins.
How it works (mechanism of action)
Contains bioactive phytochemicals (alkaloids, terpenoids, polyphenols, or glycosides) modulating cellular signalling pathways. Primary mechanisms include enzyme inhibition, receptor modulation, and transcription factor activation relevant to documented clinical indications.
📊 Effectiveness
Osteoarthritis
Evidence Grade B · 10 studies · n=880
Rheumatoid arthritis
Evidence Grade B · 8 studies · n=620
Immune function
Evidence Grade C · 8 studies · n=580
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
Autoimmune conditions: avoid. Pregnancy: avoid. Anticoagulant interaction.
💊 Drug Interactions (4)
🟡 Immunosuppressants
ModerateImmunosuppressant
Management: Avoid in transplant patients.
🟡 CYP3A4 substrates
ModerateMultiple drug classes
Management: Review all medications metabolised by CYP3A4.
⚪ Anticoagulants
MinorAnticoagulant
Management: Monitor INR. Stop 2 weeks before surgery.
⚪ Antihypertensives
MinorAntihypertensive
Management: Monitor blood pressure.
🏷️ Other Names
Uncaria tomentosa