SAFE
Capsaicin Extract
Capsicum annuum standardised capsaicin
Possibly Safe
V1 Verified
Anti-inflammatory Herbs
PubMed Studies
1,200
PubChem CID
About
Capsaicin oral supplementation for pain management via TRPV1 receptor modulation and substance P depletion.
How it works (mechanism of action)
Inhibits key inflammatory enzymes (COX-1/2, 5-LOX) or transcription factors (NF-kB, AP-1) reducing prostaglandin, leukotriene, and cytokine production. Some activate PPAR-gamma nuclear receptor mediating anti-inflammatory gene transcription.
👥 Safety by Population
🚫 Contraindications & Warnings
GI irritation: enteric coated forms preferred. Warfarin interaction. Surgery: discontinue.
🏷️ Other Names
Capsicum annuum standardised capsaicin