SAFE
Calcium orotate
Calcium orotate (Hans Nieper formulation)
Possibly Safe
V2 Verified
Minerals & Trace Elements
PubMed Studies
280
PubChem CID
About
Calcium salt of orotic acid. Promoted for superior brain penetration. Evidence base limited and contested. More expensive than conventional calcium forms.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
👥 Safety by Population
🚫 Contraindications & Warnings
Limited independent clinical evidence for superior efficacy claims. Orotic acid accumulation at very high doses: fatty liver (animal data at extreme doses). Generally safe at typical supplement doses. Less evidence than citrate or bisglycinate forms.
🏷️ Other Names
Calcium orotate (Hans Nieper formulation)