SAFE
Calcium folinate
Calcium folinate (folinic acid)
Possibly Safe
V2 Verified
Vitamins & Cofactors
PubMed Studies
49
PubChem CID
About
Reduced activated folate form. Used as leucovorin rescue in methotrexate therapy and as active folate supplement. Bypasses dihydrofolate reductase.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
👥 Safety by Population
🚫 Contraindications & Warnings
Leucovorin rescue: prescribed in methotrexate toxicity — distinguish from supplement use. Active folate — same general considerations as 5-MTHF. Does not mask B12 deficiency like folic acid. Drug interaction: methotrexate (used to rescue).
🏷️ Other Names
Calcium folinate (folinic acid)