SAFE
Calcium citrate
Tribasic calcium citrate
Likely Safe
V2 Verified
Minerals & Trace Elements
PubMed Studies
109
PubChem CID
About
Citrate salt of calcium. More soluble and better absorbed than calcium carbonate, particularly in achlorhydria. Does not require stomach acid for absorption.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
📊 Effectiveness
Bone health
Evidence Grade A · 28 studies · n=5,800 · Meta-analysis available
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
Better tolerated than CaCO3 in hypochlorhydria/PPI use. Same drug interaction separations required. Less constipating. Citrate may increase kidney stone risk in calcium oxalate stone formers — debated.
🏷️ Other Names
Tribasic calcium citrate