SAFE
Buffering agents
Citrate, phosphate, carbonate buffers
Possibly Safe
V2 Verified
Excipients & Additives
PubMed Studies
11
About
General category of pH-modifying agents including citric acid/citrates, phosphoric acid/phosphates, and carbonates. Used to maintain optimal pH for stability and dissolution. Safety depends on specific agent and quantity.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
👥 Safety by Population
🚫 Contraindications & Warnings
Individual agent profiles apply. Phosphate buffers: CKD concern (phosphate load). Citrate buffers: generally safe. Carbonate/bicarbonate: sodium load in hypertension. At typical excipient buffering quantities: generally safe.
🇪🇺 EU Health Claims Status
Art.13(1)
✓ AuthorisedNon-compliance with the Regulation because on the basis of the scientific evidence assessed, this claimed effect for this food is not a beneficial physiological effect as required by the Regulation.
Regulation EU 1924/2006 · ART13 1
🏷️ Other Names
Citrate, phosphate, carbonate buffers