SAFE
Bitter Orange Peel
Citrus aurantium peel standardised
Possibly Safe
V1 Verified
Digestive Herbs
PubMed Studies
1,200
About
Bitter orange peel contains synephrine and flavonoids with digestive, carminative, and mild stimulant effects. Different from whole bitter orange for weight loss.
How it works (mechanism of action)
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
⚖️ Regulatory Status
⚠️
CA — Restricted
Health Canada — bitter orange (synephrine) maximum dose restrictions apply in natural health products.
⚠️
EU — Restricted
EFSA (2012) — concerns about synephrine above 20mg/day from food supplements. Many EU member states have maximum dose restrictions.
⚠️
FR — Restricted
ANSES (2014) — synephrine-containing bitter orange extracts subject to maximum dose restrictions in French food supplements.
👥 Safety by Population
🚫 Contraindications & Warnings
Cardiovascular risk at high doses (synephrine). MAO inhibitor interaction. Furanocoumarins: drug interactions.
🏷️ Other Names
Citrus aurantium peel standardised