SAFE

Berberis vulgaris (Barberry)

Berberis vulgaris (root/bark extract)
Possibly Safe V2 Verified Botanicals
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PubMed Studies
880
About

European barberry containing berberine (see Phase 3 berberine entry). Used for GI infections, bile stimulation, and glucose management.

How it works (mechanism of action)

Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralPossibly safeNot established
PregnancyPossibly safeNot established
ElderlyPossibly safeNot established
🚫 Contraindications & Warnings

See berberine entry Phase 3. MAJOR drug interactions: CYP3A4/2D6 inhibition, P-gp inhibition, hypoglycaemia with diabetes medications, digoxin interaction. Pregnancy: CONTRAINDICATED.

🏷️ Other Names
Berberis vulgaris (root/bark extract)
Updated: 2026-04-02
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