SAFE

Benfotiamine

Benfotiamine (S-benzoylthiamine)
Likely Safe V1 Verified Vitamins
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PubMed Studies
29
PubChem CID
About

Fat-soluble thiamine with superior bioavailability (3.6x). Used for diabetic neuropathy and AGE damage.

How it works (mechanism of action)

Lipid-soluble thiamine achieving 3.6x higher bioavailability than thiamine HCl. Specifically inhibits three hyperglycaemic damage pathways: hexosamine pathway, DAG-PKC pathway, and AGE formation in diabetic complications.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralLikely safeNot established
PregnancyLikely safeNot established
ElderlyLikely safeNot established
🚫 Contraindications & Warnings

Very safe. Better tolerated than thiamine HCl.

🏷️ Other Names
Benfotiamine (S-benzoylthiamine)
Updated: 2026-04-11
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