PubMed Studies
18
PubChem CID
About
Apigenin is a flavone from chamomile and parsley with anxiolytic, anti-inflammatory, and neuroprotective properties.
How it works (mechanism of action)
Acts as direct free radical scavenger and indirect antioxidant via Nrf2/ARE pathway activation. Modulates inflammatory signalling via NF-kB and AP-1 inhibition. Interacts with kinase pathways (MAPK, PI3K/Akt, mTOR) and epigenetic regulators relevant to anti-ageing and disease prevention.
📊 Effectiveness
Anxiety reduction
Evidence Grade B · 8 studies · n=640
Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional
👥 Safety by Population
🚫 Contraindications & Warnings
Very safe. May interact with CYP enzymes at high doses. Additive sedation.