SAFE

Anise oil

Pimpinella anisum essential oil (anethole)
Possibly Safe V2 Verified Excipients & Additives
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PubMed Studies
3
About

Essential oil from anise seeds containing primarily trans-anethole. Used as flavouring. Oestrogenic activity of anethole at high doses documented. Star anise (Illicium verum) is a distinct species with different safety profile.

How it works (mechanism of action)

Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralPossibly safeNot established
PregnancyPossibly safeNot established
ElderlyPossibly safeNot established
🚫 Contraindications & Warnings

Trans-anethole: weak oestrogenic activity at high doses — avoid in oestrogen-sensitive conditions. Star anise (I. verum): Japanese star anise (I. anisatum) is toxic — product authenticity important. Allergy to Apiaceae family. Anticoagulant interaction at high doses.

🏷️ Other Names
Pimpinella anisum essential oil (anethole)
Updated: 2026-04-11
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