SAFE
Alpha-Lipoic Acid R-Form
R-Alpha-lipoic acid (natural isomer)
Likely Safe
V1 Verified
Antioxidants
PubMed Studies
2,200
About
Natural biologically active ALA isomer with greater potency vs racemic mixture.
How it works (mechanism of action)
Directly quenches reactive oxygen species (ROS) and reactive nitrogen species (RNS) preventing oxidative damage to DNA, proteins, and lipids. Activates endogenous antioxidant defence pathways (Nrf2/HO-1) and regenerates or spares other antioxidants through redox cycling.
👥 Safety by Population
🚫 Contraindications & Warnings
Hypoglycaemia risk with antidiabetics. Insulin autoimmune syndrome: rare association.
🏷️ Other Names
R-Alpha-lipoic acid (natural isomer)
References (1)
- European Commission. Regulation (EU) No 432/2012. Off J Eur Union. 2012;L 136:1-40. Regulatory document Source ↗
Evidence grades: SR = Systematic review / meta-analysis (highest) · RCT = Randomized controlled trial · Reg = Regulatory/official guidance