⚠️
Major drug interaction. This ingredient has clinically significant drug interactions. See Drug Interactions below before use.
SAFE

Aged Garlic Extract

aged-garlic-extract
Possibly Safe V1 Verified
Scan supplement →
Upper Safe Limit
Antiplatelet — caution with anticoagulants. Avoid high doses perioperatively.
PubMed Studies
42
PubChem CID
About

S-allylcysteine — antioxidant; reduces arterial stiffness; antiplatelet; cholesterol lowering via HMG-CoA inhibition; antihypertensive; antimicrobial; odourless

How it works (mechanism of action)

Odourless aged garlic extract used for cardiovascular health in French supplements. Kyolic brand dominant. Unlike raw garlic — no odour, better tolerated, antioxidants enhanced by ageing process.

📊 Effectiveness
Cardiovascular protection
Evidence Grade B · 14 studies · n=1,800
Possibly Effective
Blood pressure
Evidence Grade B · 18 studies · n=2,200
Possibly Effective
Cholesterol
Evidence Grade B · 14 studies · n=1,800
Possibly Effective

Evidence grades: A=Strong RCT evidence · B=Good clinical trials · C=Limited trials · D=Preliminary/traditional

👥 Safety by Population
PopulationSafety RatingMax Safe Dose
GeneralLikely safeNo established UL
🚫 Contraindications & Warnings

Consult a healthcare professional before use if pregnant, breastfeeding, taking prescription medications, or if you have a medical condition. Keep out of reach of children.

💊 Drug Interactions (2)
🔴 HIV medications (saquinavir)
Major
Antiretroviral
Management: Avoid with saquinavir-based HIV therapy.
🟡 Warfarin
Moderate
Anticoagulant
Management: Monitor INR.
References (3)
  1. National Institutes of Health. Vitamin C: Fact Sheet for Health Professionals. 2021. Available from: https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/   Reference   Source ↗
  2. European Commission. Regulation (EU) No 432/2012. Off J Eur Union. 2012;L 136:1-40.   Regulatory document   Source ↗
  3. Hallberg L, Hulthén L. Am J Clin Nutr. 2000;71(5):1147-60.   RCT   PubMed ↗

Evidence grades: SR = Systematic review / meta-analysis (highest) · RCT = Randomized controlled trial · Reg = Regulatory/official guidance

Updated: 2026-04-11
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