PubMed Studies
1
PubChem CID
About
Acacetin is a flavone from black locust flower with antiarrhythmic, anti-cancer, and anti-inflammatory properties.
How it works (mechanism of action)
Acts as direct free radical scavenger and indirect antioxidant via Nrf2/ARE pathway activation. Modulates inflammatory signalling via NF-kB and AP-1 inhibition. Interacts with kinase pathways (MAPK, PI3K/Akt, mTOR) and epigenetic regulators relevant to anti-ageing and disease prevention.
👥 Safety by Population
🚫 Contraindications & Warnings
Limited human data. CYP3A4 inhibition at high doses.